The prevalence and predictors of triple-negative breast cancer (TNBC) among newly diagnosed women in Sudan are explored in this study, which provides valuable insights into the disease's epidemiology and histopathological characteristics. The findings highlight the urgent need for improved early detection and diagnostic capabilities in the region, given the ongoing political conflict and health system collapse, along with the prevalence of poverty, limited public awareness, and deep-rooted inequalities in care delivery. The study's comprehensive approach, integrating epidemiological and histopathological perspectives, offers a more nuanced understanding of breast cancer subtypes in Sudan, particularly TNBC. The research aims to assess the frequency and distribution of TNBC and other subtypes, as well as histological classifications, and examines how these subtypes vary in terms of sociodemographic characteristics, age at diagnosis, and potential predictors. The findings underscore the importance of tailored screening, diagnostic testing, and treatment allocation strategies to address the unique challenges posed by breast cancer in Sudan, especially for TNBC cases.